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Effects of 4-aminopyridine on inward rectifying and pacemaker currents of cardiac purkinje fibres

โœ Scribed by P. P. Bogaert; D. J. Snyders

Publisher
Springer
Year
1982
Tongue
English
Weight
927 KB
Volume
394
Category
Article
ISSN
0031-6768

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Block of the cardiac pacemaker current (
Block of the cardiac pacemaker current (If) in the rabbit sino-atrial node and in canine Purkinje fibres by 9-amino-1,2,3,4-tetrahydroacridine
โœ D. DiFrancesco; F. Porciatti; D. Janigro; G. Maccaferri; M. Mangoni; T. Tritella ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Springer ๐ŸŒ English โš– 508 KB

We have investigated the action of 9-amino-1, 2, 3, 4-tetrahydroacridine (THA) on the pacemaker current If in rabbit sino-atrial node myocytes and in canine Purkinje fibers. THA at concentrations in the range 3-300 microM blocked If in a voltage-independent manner, as revealed by measurements on the