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Effectiveness of testing for anti-dna and the complement components ic3b, bb, and c4 in the assessment of activity of systemic lupus erythematosus

✍ Scribed by John D. Clough; Rose K. Chang

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
597 KB
Volume
4
Category
Article
ISSN
0887-8013

No coin nor oath required. For personal study only.

✦ Synopsis

Seventy-one patients with systemic lupus erythematosus (SLE), seen in an outpatient setting for follow-up evaluation during a 3-mo period, were tested (in addition to routine lupus monitoring studies) with enzyme immunoassays (EIAs) for anti-DNA, iC3b, and factor Bb to determine the relationship of these test results to disease activity. SLE activity was scored by four previously reported scoring systems, and six patients were identified ~ ~

as active by all four systems. We found that the EIA for anti-DNA was the best indicator of disease activity and that iC3b and Bb were not informative for this purpose in this group of patients. Mean iC3b levels were higher in a subset of seven patients with past biopsy evidence of severe (WHO class IV) glomerulonephritis than in the rest of the study population, even though none of these patients had active disease at the time of this study.

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