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Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine

โœ Scribed by Maeda, H; Hori, S; Ohizumi, H; Segawa, T; Kakehi, Y; Ogawa, O; Kakizuka, A


Book ID
118676696
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
318 KB
Volume
11
Category
Article
ISSN
1350-9047

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Cytotoxic effects of glutathione synthes
โœ Robert T. Dorr; James D. Liddil; Michelle J. Soble ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Springer US ๐ŸŒ English โš– 601 KB

The glutathione (GSH) synthesis inhibitor, buthionine sulfoximine (BSO) was tested for cytotoxicity and thiol depletion in murine and human tumor cells in vitro, and for its antitumor activity and toxicity in vivo. The cell lines used in these studies included murine L-1210 leukemia, human RPMI 8226