𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effective High-Pressure Cleavage of Sterically Hindered Steroid Esters

✍ Scribed by Wojciech Kroszczyński; Ewa Olszewska; Piotr Sałański; Janusz Jurczak

Publisher
John Wiley and Sons
Year
2004
Tongue
German
Weight
60 KB
Volume
87
Category
Article
ISSN
0018-019X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A simple and effective method to deprotect of sterically hindered steroid esters is described. Deprotection was carried out in MeOH in the presence of a catalytic amount of Et~3~N under high‐pressure conditions. Enzymatic, anionite, and high‐pressure methods are compared.

📜 SIMILAR VOLUMES

Effect of high pressure on sterically co
Effect of high pressure on sterically congested Passerini reactions
✍ Gérard Jenner 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 79 KB

The effect of high pressure is examined in 3-CC (Passerini) reactions. This effect is small when moderately hindered reactants are involved. However, particularly in the case of bulky isocyanides, the sensitivity of the reaction to pressure increases with increasing steric congestion in line with ea

Sterically hindered reactions under high
Sterically hindered reactions under high pressure. Reaction of 2,4,6-tri-t-butyl n-methylaniline with methyliodide
✍ Yoshiyuki Okamoto; Hideo Shimizu 📂 Article 📅 1968 🏛 Elsevier Science 🌐 French ⚖ 130 KB

Reactions of alkyl halides with amines to form quaternary ammonium salts have been extensively investigated with respect to steric effect between reactants and the effects of pressure on the reaction (2,j). The rate of the reaction increases with increasing applied pressure on the system, and genera