High pressure induced 1,3-cycloaddition of nitronic esters to the steroidal dipolarophiles
✍ Scribed by A.V. Kamernitzky; I.S. Levina; E.I. Mortikova; B.S. EI'yanov
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- French
- Weight
- 198 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0040-4039
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The 1,3-dipolar cycloaddition of cyclic nitrones to several "t-bromo ct,~unsaturated esters and lactones has been studied. All the reactions have shown high stereoselectivity, with a predominance of the endo or exo transition state for the trans or cis dipolarophiles, respectively.
## Abstract The regiochemistry of 1,3‐dipolar cycloaddition reactions of __C__,__N__‐diphenyl nitrone with some vinyl sulfox‐ imines as dipolarophile was investigated using density functional theory (DFT)‐based reactivity indexes and activation energy calculations at B3LYP/6‐31G(d) level of theory.