Inactivation of 1015 chimpanzee-infectio
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Dr. P. N. Lelie; H. W. Reesink; J. Niessen; B. Brotman; A. M. Prince
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Article
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1987
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John Wiley and Sons
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English
โ 396 KB
The safety of a plasma-derived hepatitis-B vaccine inactivated by two heating steps (90 sec at 103 "C followed by 10 hr pasteurization at 65 "C) was validated in chimpanzees; 1 O3 chimpanzee-infectious doses (CID,,) of hepatitis-B virus (HBV), subjected to the purification steps during production of