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Effect on Rat Progeny of Daily Administration of Meprobamate during Pregnancy and Lactation

โœ Scribed by CALDWELL, M. B.; SPILLE, D. F.


Book ID
109635801
Publisher
Nature Publishing Group
Year
1964
Tongue
English
Weight
539 KB
Volume
202
Category
Article
ISSN
0028-0836

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A single dose of 40 mg/kg of N-nitrosoethylurea (ENU) was administered to BDVI rats on the 16th day of pregnancy. The first generation descendants (F1) were mated on a brother-to-sister system to produce a second generation (F2) which was then mated to produce a third generation. A high incidence of