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Effect of zenarestat, an aldose reductase inhibitor, on endoneurial blood flow in experimental diabetic neuropathy of rat

โœ Scribed by Mikihiro Kihara; Yoshiyuki Mitsui; Mitsuaki Shioyama; Takanori Hasegawa; Mitsuo Takahashi; Shoji Takakura; Kyoko Minoura; Ikuo Kawamura

Book ID
117471975
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
99 KB
Volume
310
Category
Article
ISSN
0304-3940

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Enzyme specificity and tissue distributi
Enzyme specificity and tissue distribution of zenarestat, an aldose reductase inhibitor, and its relevance in the use of zenarestat as a therapeutic agent against diabetic neuropathy
โœ Shoji Takakura; Hideaki Minoura; Yukinori Shimoshige; Kyoko Minoura; Ikuo Kawamu ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 146 KB

## Abstract The enzyme specificity and tissue distribution of zenarestat, an aldose reductase inhibitor, was investigated in diabetic rats. Zenarestat inhibited both rat sciatic nerve aldose reductase (AR) activity and recombinant human AR with IC~50~ values of 7.5 and 44 nM, respectively. However,