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Effect of YM928, a novel AMPA receptor antagonist, on seizures in EL mice and kainate-induced seizures in rats

✍ Scribed by Hiroshi Yamashita; Kazushige Ohno; Yoko Amada; Hiroshi Inami; Jun-Ichi Shishikura; Shuichi Sakamoto; Masamichi Okada; Tokio Yamaguchi

Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
301 KB
Volume
370
Category
Article
ISSN
0028-1298

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A specific HPLC method for the simultaneous determination of YM928, a novel noncompetitive AMPA receptor antagonist, and its demethylated metabolite (YM-58875) in rat, dog and monkey plasma was developed and validated. The method utilized multiple-step liquid-liquid extraction followed by a reversed