Effect of vigabatrin and gabapentin on phenytoin pharmacokinetics in the dog
β Scribed by Kamal M. Matar; Paul J. Nicholls; Saleh A. Bawazir; Mohammed I. Al-Hassan; Asgedom Tekle
- Book ID
- 118770884
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 133 KB
- Volume
- 42
- Category
- Article
- ISSN
- 1043-6618
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
To evaluate the effects of valproic acid on the disposition of phenytoin, a single dose of 600 mg valproic acid and multiple doses of valproic acid (200 mg four times a day for 5 days) were administered together with a single oral dose of 600 mg phenytoin to 12 young male volunteers. Fraction of unb
Doxorubicin is metabolized extensively to doxorubicinol by the ubiquitous aldoketoreductase enzymes. The extent of conversion to this alcohol metabolite is important since doxorubicinol may be the major contributor to cardiotoxicity. Aldoketoreductases are inhibited in vitro by phenytoin. The presen
This study was designed to determine whether the disposition of isoxicam is influenced by the coadministration of another acidic drug, highly bound to plasma proteins and extensively metabolized, i.e., phenytoin. Ten healthy volunteers received an oral dose of 200mg of isoxicam prior to and followin