Effect of valproic acid on anxiety-related behaviors in the rat
โ Scribed by Lal, Harbans; Shearman, Gary T.; Fielding, Stuart; Dunn, Robert; Kruse, Hansjoerg; Theurer, Karin
- Book ID
- 122773622
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 427 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0361-9230
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Valproic acid (WA) is an anticonvulsant agent which produced marked choleresis in the rat. Bile flow rate increased from 50 to 60 pl per min per kg to 120 to 145 p1 per min per kg immediately after i.v. injection of VPA (37.5 to 150 mg per kg; 2 ml per kg) in male Sprague-Dawley rats. The duration o
Pregnant Sprague-Dawley rats were treated with 0, 150 or 200 mg/kg valproic acid by gavage (VPA) on days 7-18 of gestation. These doses produced no maternal toxicity, reproductive effects or effects on offspring growth and survival. Maternal plasma VPA peak levels averaged 99 and 134 micrograms/ml 1