Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health
β Scribed by Karin Dilger; Simon Hohenester; Ursula Winkler-Budenhofer; Barbara A.J. Bastiaansen; Frank G. Schaap; Christian Rust; Ulrich Beuers
- Book ID
- 116652739
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 977 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0168-8278
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π SIMILAR VOLUMES
Bile acid composition in fasting duodenal bile was assessed at entry and at 2 years in patients with primary biliary cirrhosis (PBC) enrolled in a randomized, doubleblind, placebo-controlled trial of ursodeoxycholic acid (UDCA) (10-12 mg/kg/d) taken as a single bedtime dose. Specimens were analyzed
We have compared the effect of ursodeoxycholic acid with placebo on the clinical state, blood liver chemistries and serum and urinary bile acids in four patients with primary biliary cirrhosis. All parameters were evaluated monthly, and bile acid composition was measured by capillary gas-liquid chro