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Effect of urinary pH on the disposition of methadone in man

✍ Scribed by M. -I. Nilsson; E. Widerlöv; U. Meresaar; E. Änggård


Publisher
Springer
Year
1982
Tongue
English
Weight
486 KB
Volume
22
Category
Article
ISSN
0031-6970

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The effect of omeprazole (2 mg kg-' i.v.) on respiratory depression induced in rats by acute oral methadone administration (5 mg kg-I) was examined and compared with control animals that only received methadone. Quantitative assessments of arterial pco2, po,, pH, and respiratory rate were employed