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Effect of Tumor Suppressors on Cell Cycle-Regulatory Genes: RB Suppresses p34cdc2 Expression and Normal p53 Suppresses Cyclin A Expression

โœ Scribed by Masuji Yamamoto; Mitsunori Yoshida; Koji Ono; Tsuyoshi Fujita; Naoko Ohtani-Fujita; Toshiyuki Sakai; Toshio Nikaido


Book ID
115601631
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
510 KB
Volume
210
Category
Article
ISSN
0014-4827

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Selective induction of cell cycle regula
โœ Jinsong You; R. Curtis Bird ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 962 KB

Genes encoding cdkl (~34'~''), cyclin A, cyclin B, and the tumor suppressor gene Rb are fundamental regulators of cell cycle progression which associate as a complex with the transcription factor E2F. Expression of many of these proteins has previously been shown to be repressed by okadaic acid, a s