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Expression of cyclin D2, P53, Rb and ATM cell cycle genes in brain tumors

✍ Scribed by Majid Kheirollahi; Masoud Mehr-Azin; Naser Kamalian; Parvin Mehdipour


Book ID
107577037
Publisher
Springer US
Year
2010
Tongue
English
Weight
277 KB
Volume
28
Category
Article
ISSN
1357-0560

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Genes encoding cdkl (~34'~''), cyclin A, cyclin B, and the tumor suppressor gene Rb are fundamental regulators of cell cycle progression which associate as a complex with the transcription factor E2F. Expression of many of these proteins has previously been shown to be repressed by okadaic acid, a s