✦ LIBER ✦

Effect of treatment with intravenous immunoglobulin on quality of life in patients with stiff-person syndrome

✍ Scribed by Willibald Gerschlager; Peter Brown

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 53 KB
Volume: 17
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.10043

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✦ Synopsis

The therapeutic effects of intravenous immunoglobulin (IVIG) on the stiff-person syndrome (SPS) have been described exclusively in case reports or open-label studies in terms of clinical outcomes. We investigate whether IVIG improves quality of life (QoL) in the SPS. Six patients with the classic form of SPS completed a generic QoL instrument, the SF-36, and a Visual Analogue Scale (VAS) before treatment as well as 2 weeks after completion of a course of IVIG. There was significant improvement in the SF-36 subscores for pain, social functioning, general mental health, and energy-vitality with treatment. The VAS also improved significantly. We conclude that treatment with IVIG improves QoL in the SPS.

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