Deleterious effects of intravenous immunoglobulin in a patient with thrombotic thrombocytopenic purpura
โ Scribed by Jean Marc Durand; Patrice Lefevre; Gilles Kaplanski; Frederique Retornaz; Elodie Cretel; Jacques Soubeyrand
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 258 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0361-8609
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## Abstract An immunologic mechanism, possibly immune complex mediated, has been suggested as the basis for the pathogenesis of thrombotic thrombocytopenic purpura (TTP). The evidence supporting this concept has been the association of TTP with systemic lupus erythematosus and the successful therap
Elevated serum lactate dehydrogenase (LDH) is a characteristic finding in patients with thrombotic thrombocytopenic purpura (TTP). It is widely accepted that total serum LDH principally rises due to the release of red blood cell LDH as a consequence of intravascular hemolysis. To identify the cellu
## Abstract Intravenous immunoglobulin (IGIV) therapy is generally considered to be a safe and effective treatment for idiopathic thrombocytopenic purpura (ITP). The usual initial treatment dose is 1โ2 g/kg body weight, which results in an extended infusion time, significantly impacting patients' d