Effect of the regulatory subunit of cAMP-dependent protein kinase on the genetic activity of eukaryotic cells
✍ Scribed by Maria V. Nesterova; Alexander I. Glukhov; Evgenii S. Severin
- Publisher
- Springer
- Year
- 1982
- Tongue
- English
- Weight
- 641 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0300-8177
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## Abstract Characterization of the unfolding dynamics of a recombinant type IA regulatory subunit (RIα) of cyclic adenosine monophosphate (cAMP)‐dependent protein kinase (cAPK) was examined by CE with UV detection. Electrophoretic separation of RIα by CE in a buffer devoid of cAMP resulted in rapi
Localization of the regulatory subunit of cAMP-dependent protein kinase type II was studied in proliferating and quiescent fibroblasts 3T3 and in a cell line of neural origin pheochromocytoma PC12. In actively proliferating PC12 cells the regulatory subunit was found to be localized in the nucleus.
CAMP-binding regulatory subunits (RI Or RI1) but share a common catalytic subunit (C) (9,14). RI and RII Medica,
## Abstract Conflicting reports have attributed 8‐chloro‐cAMP (Cl‐cAMP)‐mediated inhibition of tumor cell growth to either a toxic 8‐chloro‐adenosine (Cl‐AdR) breakdown product or a Cl‐cAMP‐mediated decrease in ratio of Type I to Type II regulatory (R) subunits of protein kinase A (PKA). Using the