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Effect of the P-glycoprotein inhibitor, SDZ PSC 833, on the blood and brain pharmacokinetics of colchicine

✍ Scribed by Sandrine Desrayaud; Pierrette Guntz; Jean-Michel Scherrmann; Michel Lemaire

Book ID
117175091
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
865 KB
Volume
61
Category
Article
ISSN
0024-3205

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The objective of this study was to investigate the in vivo influence of the P-glycoprotein (P-gp) inhibitor PSC833 on the plasma pharmacokinetics, total brain concentrations and tail-flick latency of oxycodone in rats. Eight rats each received an infusion of PSC833 or vehicle without PSC833. One hou