𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of the novel antipsychotic drug perospirone on P-glycoprotein function and expression in Caco-2 cells

✍ Scribed by Yan-Gang Zhou; Kun-Yan Li; Huan-De Li

Publisher
Springer
Year
2008
Tongue
English
Weight
206 KB
Volume
64
Category
Article
ISSN
0031-6970

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Experimental demonstration of the unstir
Experimental demonstration of the unstirred water layer effect on drug transport in Caco-2 cells
✍ Kazumasa Naruhashi; Ikumi Tamai; Qing Li; Yoshimichi Sai; Akira Tsuji πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 86 KB

We previously demonstrated that P-glycoprotein and MRP2 contribute to the secretory transport of grepafloxacin in the small intestine. Although inhibitors of these secretory transporters increased absorptive transport of grepafloxacin, secretory transport was not altered in Caco-2 cells, as determin

Effects of hypotonic and hypoionic media
Effects of hypotonic and hypoionic media on drug pumping by P-glycoprotein expressed in epithelial and nonepithelial cell lines
✍ Karina Ambasch; Z. Ioav Cabantchik; Itzchak N. Slotki πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 643 KB

## Abstract The effects of anisotonic and anisoionic media on the drug‐pumping function of P‐glycoprotein (Pgp) were studied in epithelial and nonepithelial cells. We used HT‐29 colon cells (HT‐29/Pgp^βˆ’^) induced to express Pgp and MDR phenotype (HT‐29/Pgp^+^) and NIH3T3 (3T3/Pgp^βˆ’^) cells which we

Investigation of the coordinated functio
Investigation of the coordinated functional activities of cytochrome P450 3A4 and P-glycoprotein in limiting the absorption of xenobiotics in Caco-2 cells
✍ Christine D.H. Tran; Peter Timmins; Barbara R. Conway; William J. Irwin πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 233 KB

The coordination of the functional activities of intestinal CYP3A4 and P-gp in limiting the absorption of xenobiotics in Caco-2 cells was investigated. Growing Caco-2 cells were exposed to increasing concentrations of doxorubicin (1Β±2 mM) in plastic Β―asks to encourage a subpopulation of cells, that