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Effect of the ebna-2 gene on the surface antigen phenotype of transfected ebv-negative B-lymphoma lines

✍ Scribed by Pierre Åman; Martin Rowe; Chieko Kai; JÜRgen Finke; Lars Rymo; Eva Klein; George Klein

Book ID
102864124
Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
660 KB
Volume
45
Category
Article
ISSN
0020-7136

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✦ Synopsis

Two EBV-negative B-lymphoma cell lines with different phenotypes were transfected with the Epstein-Barr virus EBNA-2 gene. The effects on the expression of 8 B-cell surface markers were analyzed by immunofluorescence methods. In one of the EBNA-2 transfected cell lines, the expression of the CR2 receptor CD2I was induced and the expression of CD23 was enhanced. The results suggest that the EBNA-2 gene is involved in the regulation of CD2l and CD23 in EBV-carrying cells.

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