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Effect of the basicity of the aza group on the direction of nucleophilic substitution reactions in imidazo[4, 5-f]quinolines

✍ Scribed by B. I. Khristich; V. A. Kruchinin; A. F. Pozharskii; A. M. Simonov


Book ID
112330002
Publisher
Springer US
Year
1971
Tongue
English
Weight
355 KB
Volume
7
Category
Article
ISSN
0009-3122

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Nucleophilicity and Basicity in the Quat
✍ Cyril A. Grob; Markus G. Schlageter πŸ“‚ Article πŸ“… 1977 πŸ› John Wiley and Sons 🌐 German βš– 365 KB πŸ‘ 1 views

## Abstract The second order rate constants (__k__) for quaternization of thirty 4‐substituted quinuclidines (**1**) by methyl iodide in methanol have been measured. The effects of the substituents on rate are relatively small and indicate an early transition state with little charge separation. Th