Effect of Temperature on 5-endo-and 4-exo-trig Radical Cyclizations of N-Vinylic α-Halo Amides. -The reaction course is found to depend on the temperature. The method provides a new entry to tetrahydroindoles as versatile synthetic intermediates.
Effect of Temperature of 5-Endo- and 4-Exo-Trig Radical Cyclizations of N-Vinylic α-Halo Amides
✍ Scribed by Hiroyuki Ishibashi; Masahiro Higuchi; Masashi Ohba; Masazumi Ikeda
- Book ID
- 104258458
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 540 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Total Synthesis of (-)-γ-Lycorane Using Diastereoselective 5-endotrig Radical Cyclization of N-Vinylic α-Halo Amides. -Radical cyclization of the acetamides (IV) proceeds with only moderate diastereoselectivity. Major product (Va) is converted to the title alkaloid (XI). -
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