Effect of tamoxifen on arterial microvascular anastomosis

✍ Scribed by Breno Bezerra Gomes De Pinho Pessoa; Bruno Bezerra Menezes Cavalcante; Munique Pinheiro Maia; Haroldo H. Ribeiro Filho; Marcia Kiyomi Koike; Salustiano Gomes De Pinho Pessoa; Luiz Gonzaga Porto Pinheiro; Edna Frasson De Souza Montero

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 129 KB
• Volume: 27
• Category: Article
• ISSN: 0738-1085
• DOI: 10.1002/micr.20357

✦ Synopsis

Abstract

Breast reconstruction after cancer treatment is based on the circulation of pedicle and microvascular flaps. This article aimed to verify the effect of tamoxifen (TMX) pretreatment in arterial anastomosis in rats. Twenty female Wistar rats were equally divided into two groups. TMX (0.3 mg/kg) was administered to the experimental group for 2 weeks orally. After this period, the right femoral artery was sectioned and a terminoterminal anastomosis performed. The same procedure was done in the control group, except that the animals received the vehicle without TMX. One week later, the femoral arteries were inspected for flow through the anastomosis, and the vessel near it was sent to light microscopic examination. It was observed mild vasculite in both groups. The intimal thickness and total vessel wall in the TMX‐treated group was significantly higher. A real thrombotic effect upon the arterial vascular anastomosis was not observed, eventhough, TMX induced intimal hyperplasia. © 2007 Wiley‐Liss, Inc. Microsurgery 2007.