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Effect of surfactants on epidermal permeability in rabbits

✍ Scribed by Michael Mezei; Kevin J. Ryan

Publisher
John Wiley and Sons
Year
1972
Tongue
English
Weight
354 KB
Volume
61
Category
Article
ISSN
0022-3549

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✦ Synopsis

The rate of water dcsorption of untreated and surfactant-treated depilated rabbit skin was determined to supplement previous data of surfactant-induced changes in biological membranes. The compounds applied were petrolatum USP alone (control) and petrolatum containing 10% polysorbate 85, 10% polyoxyethylene ether 96. or 10% sorbitan trioleate. Skin slices 0.4 mm. thick, were placed in a constant-temperature and constant-humidity chamber, and water-vapor loss was continuously recorded with an electric microhalance. The water desorption rate was invariably greater with surfactant-treated than with control skin. The results confirm earlier findings that the tested surfactants affect membrane structure, thereby probably increasing permeability.

Keyphrases 0 Surfactants-effect on epidermal permeability in rabbits. water desorption rates 0 Permeability. epidermal---effect of surfactants, rabbits 0 Skin permeability, rabbits-effect of surfactants, water desorption rates

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