InVivo method for monitoring polysorbate 85 effect on epidermal permeability
✍ Scribed by Kevin J. Ryan; Michael Mezei
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 326 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
An in uiuo method of monitoring the rate of water desorption from human forearms, using "dry" nitrogen gas passed over approximately 1 cm2 of skin was investigated with the aid of a commercial electrolytic moisture analyzer. The assembled apparatus was used to evaluate the differences in water loss rates from treated and untreated (control) forearms following surfactant application. The changes in the differences were also monitored after cessation of treatment, i.e., during the healing process. The apparatus provided an accurate, rapid, and painless method of monitoring relative water loss rates and, as such, could prove a useful tool in routine testing in experimental dermatology and cosmetology. The results confirm the earlier finding from an in uitro method with excised rabbit skin that the tested surfactant increases the permeability of the epidermis.
Keyphrases Permeability, epidermal-in uiuo method for monitoring effect of polysorbate 85, relative water loss rates Epidermis-permeability, in uiuo method for monitoring effect of polysorbate 85, treated and untreated human epidermis 0 Polysorbate 85-effect on epidermal permeability, in uiuo method for determining relative water loss rates 0 Water loss rates-human epidermis, in uiuo method MEECO, model W, type SPR, Manufacturers Engineering & Equipment Coleman 165.