Use of a genetic algorithm in the develo
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D. Weuster-Botz; V. Pramatarova; G. Spassov; C. Wandrey
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Article
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1995
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Wiley (John Wiley & Sons)
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English
⚖ 832 KB
The production process for Arthrobacter simplex with high specific hydrocortisone A'-dehydrogenase activity was improved by medium optimization in parallel shake flask experiments. Using a genetic algorithm, the concentrations of 12 medium components (mineral salts and amino acid) were optimized wit