Effect of sulphur mustard inhalation exposure on some urinary variables in mice

✍ Scribed by Om Kumar; R. Vijayaraghavan

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 42 KB
• Volume: 18
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/(sici)1099-1263(199807/08)18:4<257::aid-jat501>3.0.co;2-4

✦ Synopsis

The effect of sulphur mustard (2,2Ј-dichlorodiethyl sulphide) exposure through inhalation at 0.5. 1.0 and 2.0 lc 50 (21.2, 42.3 and 84.6 mg m ؊3 for 1 h) on some urinary variables was studied in female mice at 6, 24 and 48 h and 7 days post-exposure. The urinary excretion and circulatory blood accumulation of uric acid increased significantly. The level of creatine was also elevated significantly as compared to the control at 2 lc 50 . It is concluded that sulphur mustard alkylates DNA and triggers catabolism of apurinated purine bases in a very short time. The increase in uric acid excretion in urine can be detected only when the exposure concentration is high.