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Effect of sulfated GAGs on the expression and activation of MMP-2 and MMP-9 in corneal and dermal explant cultures

✍ Scribed by N. Isnard; L. Robert; G. Renard


Book ID
108485581
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
164 KB
Volume
27
Category
Article
ISSN
1065-6995

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Enhanced expression of the type IV collagenases MMP-2 and MMP-9, or lack of their inhibitors TIMP-1 and TIMP-2, has been associated with tumour invasion and metastatic potential in several experimental models. Regulation of enzyme activity is clearly a key step in tumour invasion, and recently a pot