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P-448 Clinicopathological significance of MMP-2,9, and MT-MMP mRNA expressions in hepatocellular carcinoma and the effect of MMP-9 inhibitor

✍ Scribed by T Harada; S Arii; M Mise; H Higashitsuji; M Furutani; S Ishigami; M Niwano; M Imamura; K Tamaki; K Tanzawa


Book ID
113402335
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
125 KB
Volume
3
Category
Article
ISSN
0928-4346

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Enhanced expression of the type IV collagenases MMP-2 and MMP-9, or lack of their inhibitors TIMP-1 and TIMP-2, has been associated with tumour invasion and metastatic potential in several experimental models. Regulation of enzyme activity is clearly a key step in tumour invasion, and recently a pot