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Effect of Structural Modification of the Hydantoin Ring on Anticonvulsant Activity

✍ Scribed by Cortes, Sergio; Liao, Zeng-Kun; Watson, Darrell; Kohn, Harold


Book ID
118018583
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
789 KB
Volume
28
Category
Article
ISSN
0022-2623

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The lethal doses, neurotoxic doses, anticonvulsant potencies, and protective indices for two chlorinated barbiturates, 5-(4-chlorophenyl)-5-ethylbarbituric acid (monochloro) and 5-(3,4-dichlorophenyl)-5-ethylbarbituric acid (dichloro), were determined in mice and the results compared with similar va