Effect of stobadine on oxygen free radical generation in stimulated human polymorphonuclear leukocytes
✍ Scribed by J. Pečoivová; K. Drábiková; K. Kotuliaková; T. Mačičková; R. Nosál; E. Danihelová
- Book ID
- 117176507
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 221 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0024-3205
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## Abstract The chemiluminescence (CL) technique with luminol and isoluminol was used to characterize the effect of stobadine on reactive oxygen metabolites (ROM) generation in human whole blood and in isolated polymorphonuclear leukocytes (PMNL) stimulated with N‐formyl‐methionyl‐leucyl‐phenyl‐ala
Oxygen free radicals (OFRs) have been suggested in the pathogenesis of Parkinson's disease (PD). These free radicals exert their cytotoxic effect by peroxidation of lipid membrane resulting in the formation of malondialdehyde (MDA). Polymorphonuclear (PMN) leukocyte is one of the major sources of OF