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Oxygen free radical producing activity of polymorphonuclear leukocytes in patients with Parkinson's disease

✍ Scribed by Jawahar Kalra; Ali H. Rajput; Subrahmanyam V. Mantha; Ajai K. Chaudhary; Kailash Prasad

Publisher
Springer
Year
1992
Tongue
English
Weight
424 KB
Volume
112
Category
Article
ISSN
0300-8177

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✦ Synopsis

Oxygen free radicals (OFRs) have been suggested in the pathogenesis of Parkinson's disease (PD). These free radicals exert their cytotoxic effect by peroxidation of lipid membrane resulting in the formation of malondialdehyde (MDA). Polymorphonuclear (PMN) leukocyte is one of the major sources of OFR. However, the oxygen free radical producing activity of PMN leukocytes in patients with PD is not known. We therefore studied the oxygen free radical producing activity of polymorphonuclear leukocytes and MDA levels in the serum of healthy subjects and in patients with Parkinson's disease. The oxygen free radical producing activity of PMN leukocytes in blood and the MDA content in serum were significantly higher in patients with Parkinson's disease than in healthy subjects. These results indicate a possible role of oxygen free radicals in the pathogenesis of Parkinson's disease.

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