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Effect of sonic oscillation upon “old” and “new” nucleic acids in Escherichia coli

✍ Scribed by Avram Goldstein; Beverly J. Brown

Book ID
115790301
Publisher
Elsevier Science
Year
1961
Weight
582 KB
Volume
53
Category
Article
ISSN
0006-3002

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To investigate the antisense effect of a pyrrolidine-based oxy-peptide nucleic acid (POPNA), we carried out the LacZ reporter assay using a 12-mer trans-l-POPNA conjugated with a cell-penetrating peptide (antisense reagent). The antisense effect of the conjugated POPNA (inhibition of LacZ activity)