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Effect of smoking and CYP2D6 polymorphisms on the extent of fluvoxamine–alprazolam interaction in patients with psychosomatic disease

✍ Scribed by Hideyo Sugahara; Chiharu Maebara; Hisakazu Ohtani; Masanori Handa; Katsumi Ando; Kazunori Mine; Chiharu Kubo; Ichiro Ieiri; Yasufumi Sawada

Publisher
Springer
Year
2009
Tongue
English
Weight
146 KB
Volume
65
Category
Article
ISSN
0031-6970

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✍ Tatsuhiko Yagihashi; Masafumi Mizuno; Bun Chino; Yuji Sato; Kei Sakuma; Toru Tak 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 121 KB

## Abstract ## Objective Risperidone is converted to 9‐hydroxyrisperidone by CYP2D6. Two parameters were used to examine the influences of CYP2D6 polymorphism and of co‐medication on risperidone metabolism: the risperidone:9‐hydroxyrisperidone concentration ratio (R:9‐OHR ratio) and the sum of the