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Effect of silibinin on the pharmacokinetics of nitrendipine in rabbits

โœ Scribed by Voruganti, Swathi; Yamsani, Shravan Kumar; Yamsani, Madhusudan Rao

Book ID
124102355
Publisher
Springer-Verlag
Year
2013
Tongue
English
Weight
214 KB
Volume
39
Category
Article
ISSN
0378-7966

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## Abstract The interaction between indomethacin (IND) and methotrexate (MTX) was investigated in rabbits. The study was designed so as to evaluate the effect of IND (1 mg h^โˆ’1^) during a continuous MTX infusion (1ยท2 mg kg^โˆ’1^) over 240 min. IND was injected i.v. at hourly intervals after a steady