EFFECT OF SHORT-TERM ADMINISTRATION OF CHOLESTYRAMINE AND CHENODEOXYCHOLIC ACID ON 7ALPHA-HYDROXY-4-CHOLESTEN-3-ONE CONCENTRATION
β Scribed by Kovar, J.; Lenicek, M.; Vitek, L.; Pitha, J.
- Book ID
- 118636670
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 70 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1567-5688
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π SIMILAR VOLUMES
Evidence was recently presented that an essential part of the accumulation of cholestanol in patients with cerebrotendinous xanthomatosis is due to acceleration of a novel pathway, involving ?a-hydroxylated intermediates in bile acid biosynthesis as precursors (J. Clin. Invest. 1986; 75:448-456). Su
tive pathway bypasses cholesterol 7a-hydroxylase activity. Serum concentrations of 7a-hydroxy-4-cholesten-3-Studies on rat and human hepatocytes in cell culture indicate one (a-HC) have recently been shown to reflect the activthat bile acid synthesis from 27-hydroxycholesterol might acity of cholest