✦ LIBER ✦

Effect of serotonin 1A agonist tandospirone on depression symptoms in senile patients with dementia

✍ Scribed by Yutaka Masuda; Yusuke Akagawa; Yasuo Hishikawa

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 41 KB
Volume: 17
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.393

No coin nor oath required. For personal study only.

✦ Synopsis

The treatment of depression in senile patients with dementia is difficult with the drugs used formerly. The effects of a new anxiolytic drug, tandospirone, were investigated on depression symptoms in nine senile patients with dementia using Hamilton Depression Rating Scale (HAM-D) items. Tandospirone improved the symptoms, especially the depressive mood, agitation and anxiety, although a slight gastrointestinal symptom was found in one patient. The findings in the present study may suggest that tandospirone is a useful and comparatively safe drug for depression symptoms in senile patients with dementia.

📜 SIMILAR VOLUMES

Effect of olanzapine on cognition during

Effect of olanzapine on cognition during treatment of behavioral and psychiatric symptoms in patients with dementia: a post-hoc analysis

✍ Walter G. Deberdt; Alan Siegal; Jonna Ahl; Adam L. Meyers; Ronald Landbloom 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 71 KB 👁 1 views

## Abstract ## Objective This study was conducted to determine the effect of olanzapine treatment on cognition in elderly patients with behavioral and psychiatric symptoms (BPSD) associated with dementia. ## Methods This was a post‐hoc analysis of three randomized double‐blind, clinical trials o

Effects of acute and long-term treatment

Effects of acute and long-term treatment with the serotonin1A agonist gepirone on hippocampal afterdischarges in rats

✍ Yuji Wada; Jun Shiraishi; Mitsuhiko Nakamura; Naohisa Hirao; Yoshifumi Koshino 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 991 KB

We assessed the effects of acute and long-term administration of gepirone, a serotonin,,(5HT,,) agonist, on hippocampal afterdischarges (ADS) elicited by electrical stimulation in rats. Acute single injection of gepirone at 10 mg/kg produced a significant reduction in the AD threshold, with a signif