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Effect of selected amino acids on ethanol toxicity in rats

โœ Scribed by Rudolph J. Breglia; Charles O. Ward; Charles I. Jarowski

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
853 KB
Volume
62
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

The effects of L-lysine, L-arginine, L-ornithine, and glycine on acute ethanol intoxication, and the degree of ethanolinduced CNS depression, were investigated. Amino acid treatment was showp to prolong the onset of ataxia, reduce the duration of sleeping time, and decrease the number of rats losing the righting reflex, but it did not alter the LDsp values in response to ethanol. The protective actions of the amino acids are attributed to the formation of an amino acid-acetalaehyde complex, although other possible interactions are discussed.

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