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Effect of scatter factor and hepatocyte growth factor on motility and morphology of mdck cells

โœ Scribed by Yuan LI; Ansamma Joseph; Madhu M. Bhargava; Eliot M. Rosen; Toshikazu Nakamura; Itzhak Goldberg


Book ID
112923761
Publisher
Society for In Vitro Biology
Year
1992
Tongue
English
Weight
495 KB
Volume
28
Category
Article
ISSN
1475-2689

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Hepatocyte growth factor, a potent mitogen for epithelial and other cell types, and scatter factor, a stimulant of epithelial cell motility are identical. In addition to these mitogenic and motogenic functions, the factor has been shown to be an epithelial morphogen and also has antiproliferative ef

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The scatter factor is a protein released by fibroblasts that causes dispersal of epithelial cell colonies and disruption of intercellular junctions, as well as an alteration of morphology with ruffling and rapid extension and movement of pseudopodia. To find out if the scatter factor has a direct ef