✦ LIBER ✦

The biology of hepatocyte growth factor/scatter factor

✍ Scribed by Robert A. Furlong

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 698 KB
Volume: 14
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950140908

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✦ Synopsis

Hepatocyte growth factor, a potent mitogen for epithelial and other cell types, and scatter factor, a stimulant of epithelial cell motility are identical. In addition to these mitogenic and motogenic functions, the factor has been shown to be an epithelial morphogen and also has antiproliferative effects in some cancer cell lines. The mernbrane receptor for hepatocyte growth factor1 scatter factor has been identified as the c-met proto-oncogene product. Madin-Darby Canine Kidney (MDCK) cells: (a) control; (b) addition of 32 units of scattcr factor. Reprinted by kind permission of the authors from Nurure 327, pp 239-242. Copyright 0 19x7 MacMillan Magazines Ltd.

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