Effect of sample viscosity on the behavior of thin-channel flow-through dialyzers in flow-injection analysis

✍ Scribed by Lars Risinger; Gillis Johansson

• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 535 KB
• Volume: 261
• Category: Article
• ISSN: 0003-2670
• DOI: 10.1016/0003-2670(92)80224-u

✦ Synopsis

VISCOUS samples unll cause pressure changes which affect the transfer of solutes through an on-lme dlalyzer Pressure changes can cause pre-peaks m the recorded slgnal due to membrane movements The flow-rate m the reuxver channel mcreases temporanly as the pressure budds up A pressure dtfferentml of 30 kPa forced 1% of the ltquld (at 0 4 ml mm-') through the membrane to the side wth the lower pressure This hydrodynanuc flow wdl Influence the dfislonally drwen transfer of solutes and may cause analykal errors The design of a flow-lqltion analysts (PIA) system wth a flow-through dlalyzer IS dIscussed The membrane should be stti, unth a low solvent transport rate to mmumze fluctuattons of the response due to changes of the dtierential pressure when a viscous sample 1s passmg the &alyzer The system should be made unth stti components and wtthout flow restnctors after the dralyzer on the sample side