Effect of salts on the stereoselectivity of reactions of α-lithio sulfoxides
✍ Scribed by T. Durst; M. Molin
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- French
- Weight
- 208 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Addition of 2 equiv of a lithio-acetylide to an unprotected a-hydroxy ketone is extremely stereoselective in examples where the two ketone substituents are relatively large.
## Abstract Good to excellent stereoselectivities were achieved in the reductive cyclization (with Et~3~SiH/trimethylsilyl trifluoromethanesulfonate (TMSOTf)) of enantiopure hydroxy sulfinyl ketones en route to 2,5‐__cis__‐disubstituted tetrahydrofuran skeletons. Electrostatic effects of the exocyc
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