Effect of salmeterol on polymorphonuclear leukocyte (PMNL) chemiluminescenceIn Vitro

✍ Scribed by Ramage, Lynn ;Blair, Andrea L. ;Cree, Lan A. ;Dhillon, D. Paul

• Publisher: John Wiley and Sons
• Year: 1993
• Weight: 463 KB
• Volume: 8
• Category: Article
• ISSN: 0884-3996
• DOI: 10.1002/bio.1170080504

✦ Synopsis

Abstract

Although beta‐agonists remain an important aspect of the treatment of asthma, their role has recently been questioned. Salmeterol has recently been developed as a betaagonist with prolonged bronchodilator action. Using lucigenin‐enhanced chemiluminescence, we have shown that salmeterol inhibits this aspect of phagocyte function in vitro in a concentration‐dependent manner. However, salmeterol differs from classical beta~2~‐agonists in that at concentrations between 10^−5^ and 10^−3^ mol/L, its effects on phagocytes cannot be completely reversed by washing the cells or by propanolol. The effects on phagocytes may not therefore be explicable on the basis of betaadrenergic mechanisms alone.