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Effect of reticuloendothelial system stimulation on resistance to rous sarcoma virus infection in chicks

โœ Scribed by Emile G. Bliznakov

Publisher
John Wiley and Sons
Year
1968
Tongue
French
Weight
570 KB
Volume
3
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

By using a nun-toxic reticu/oendothelial system stimulant, lipid-Restim, derived from shark livers, we were able to demonstrate the following efiects on growing Rous sarcoma tumors in young chicks. Prechallenge Restim treatment: Significant reduction of the percentage of chicks with tumors and prolongation of the latent period resulted from combined administration of Restim and speciftc antiserum.

Postchallenge Restim treatment: The mortality data indicated that there was a significant increase in survival time and survival rate. Complete regressions occurred in a significant number of the Restim-treated chicks compared to the controls. Possible explanaiions of these findings arc discussed.

' The tern1 " regression " is used in this paper to mean complete macroscopical disappearance of the primary tumor at the site of inoculation of the virus.

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