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Effect of recombinant human interleukin-6 on nitrite production of mouse myeloid leukemia cells

โœ Scribed by Kuniaki Takagi; Tsutomu Hosaka; Yasunobu Suketa

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
412 KB
Volume
147
Category
Article
ISSN
0021-9541

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โœฆ Synopsis

The effect of recombinant human interleukin-6 (rhlL-6) on induction of nitrite (NO;) production was investigated in a mouse myeloid leukemia cell line ( M l ) and a subclone ( M m l ) . NO; was induced by rhlL-6 P.50 Uiml) in these cell lines. Pretreatment with rhlL-6 (100 Uiml) for 1 day synergistically enhanced the production of NO; in Mrnl by LPS. Furthermore, pretreatment with IL-6 (100 U/ml) shortened the lag time of induction. These results indicate that IL-6 is involved in the regulation of the NO, production in macrophdge-like cells.

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