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Effect of recombinant human interferon-alpha/2b on epidermal-growth-factor-, estrogen- and progesterone-receptor expression in primary cervical cancer

✍ Scribed by Giovanni Scambia; Pierluigi Benedetti Panici; Gabriella Ferrandina; Francesco Battaglia; Gigliola Sica; Ferdinando Coronetta; Carlo Rumi; Salvatore Mancuso

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
578 KB
Volume
58
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The effects of a short period of in vivo systemic rh‐IFN‐alpha/2b treatment on epidermal‐growth‐factor(EGFR)‐, estrogen(ER)‐ and progesterone (PR)‐receptor content in 11 primary human cervical tumors was investigated by the radioreceptorial technique. EGFR levels were found to be significantly higher in cervical tumors after rh‐IFN‐alpha/2b treatment with respect to basal levels. In 2 cases, immunohistochemical and cytofluorimetric analysis showed that rh‐IFN‐alpha/2b treatment induces an increase in EGFR immunoreactivity and in the fraction of EGFR‐positive cells. No difference in ER and PR levels in cervical tumors before and after rh‐IFN‐alpha/2b treatment was observed. Our results suggest that rh‐IFN‐alpha/2b up‐regulates EGFR in primary human cervical tumors in vivo.

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