Effect of recombinant human granulocyte-macrophage colony-stimulating factor (rhuGM-CSF) on normal peripheral B lymphocytes and B lymphoblastoid cell lines
โ Scribed by Rainer Haas; Stefan Hohaus; Sophie Kiesel; Elisabeth Ogniben; Werner Hunstein
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 472 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0165-2478
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๐ SIMILAR VOLUMES
Granulocyte-macrophage colony-stimulating factor (GM-CSF) (250 microg/m2) was administered subcutaneously to 7 normal volunteers for up to 14 days to study its effects on neutrophil kinetics and function. With treatment, blood neutrophil counts rose gradually to peak at 3 1/2 times baseline by day 1
We have found that GM-CSF and DMSO have antagonistic effects on the proliferation but not maturation of asynchronously growing HL-60 cells such that growth in the presence of both more closely resembles normal hematopoiesis (Brennan et al., J. Cell Physiol. 132:246, 1987). Studies were undertaken to
SUMMARY: The bronchial epithelium produces cytokines that could contribute to inflammatory events in airways. In this study we determined the basal and TNF \(\alpha\) stimulated productions of GM-CSF and IL-8 by human bronchial epithelial cells (HBEC) collected from 12 control and six asthmatic pati