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Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx)

✍ Scribed by Kristin J. Metry; Jason R. Neale; Mark A. Doll; Ashley L. Howarth; J. Christopher States; W. Glenn McGregor; William M. Pierce Jr.; David W. Hein


Book ID
113809404
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
685 KB
Volume
684
Category
Article
ISSN
0027-5107

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## Abstract 2‐Amino‐3‐methylimidazo[4,5‐__f__]quinoline (IQ) and 2‐amino‐3,8‐dimethylimidazo[4,5‐__f__]quinoxaline (MelQx) are carcinogens found in cooked meats that form DNA adducts upon metabolic activation. Purified DNA from Chinese hamster ovary (CHO) cells was reacted in vitro with the active