Effect of Pyrazole and Dexamethasone Administration on Cytochrome P450 2E1 and 3A Isoforms in Rat Liver and Kidney: Lack of Specificity of p-Nitrophenol as a Substrate of P450 2E1
✍ Scribed by Alain Zerilli; Danièle Lucas; Yvonne Dreano; Daniel Picart; François Berthou
- Book ID
- 109120172
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 722 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0145-6008
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## Abstract Cytochrome P450 (CYP) 2A6 and __CYP2E1__ are enzymes with a high ability to activate a nitrosamine, 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK), to its potent and ultimate carcinogens. The polymorphic __CYP2A6__ and __CYP2E1__ have been implicated in increased susceptibility to